Research Interests
Cell cycle progression and cell growth in mammalian cells. Working on a global proteomic and metabolomic characterization of a proliferative cellular transition in a mouse lymphocyte cell line. Also, interested in mechanisms of the G1 phase and restriction point and cell size regulation through experiments and theoretical modeling. Some related interests are in the short G1 phase of embryonic stem cells and the clonal expansion of B-cells in the immune system. Another project involves in silico evolution of segmentation or expression patterns of the Drosophila gap genes using a logical model, developing selection and mutation models with Eugene Shakhnovich and Denis Thieffry. Also, computational works on transcriptional combinatorial regulation and co-regulation of protein complexes in yeast are in progress.