Research Interests
Cell cycle progression and cell growth in mammalian cells.
Particularly interested in mechanisms of the G1 phase and restriction
point and cell size regulation through experiments and theoretical
modeling. Some related interests are in the short G1 phase of embryonic
stem cells and the clonal expansion of B-cells in the immune system.
Another project involves in silico evolution of segmentation or
expression patterns of the Drosophila gap genes using a logical model,
developing selection and mutation models with Eugene Shakhnovich and
Denis Thieffry. Also, computational works on transcriptional combinatorial
regulation and co-regulation of protein complexes in yeast are in
progress.
Background
Previous post-doctoral research in biophysics and molecular
evolution in Eugene Shakhnovich's group at Harvard: transcriptional
co-regulation of protein complexes in yeast, in silico evolution of
expression patterns of Drosophila gap genes. PhD research in
bioinformatics/functional genomics at Max Planck Institute for Molecular
Genetics, Berlin, Germany: computational and statistical analyses of
genome-/proteome-wide data such as ChIP-chip, gene expression,
protein-protein interactions, protein complexes, and functional annotations
in S. cerevisiae, focusing on transcriptional networks. Original background
in theoretical physics, especially black holes and string theory, in Cambridge
and Swansea, UK.